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Raffaele Spano

Support Technician
Nanotechnology for Precision Medicine
Research center
About

Dr. Raffaele Spanò is a Support Technician in the Nanotechnology for Precision Medicine research line at Istituto Italiano di Tecnologia since July 2019. His research activities focus on the development of Discoidal Polimeric Nanoconstructs carrying thrombolytic drugs (e.g., Tissue-Type Plasminogen Activator) for therapeutic applications in vascular diseases.

In January 2013, he started his Ph.D. in Tissue Engineering and Regenerative Medicine under the supervision of Prof. Ranieri Cancedda and Dr. Maddalena Mastrogiacomo. During this period, he worked on the development of a Human Platelet-Rich Plasma-based additive for cell culture, and skin dressings to enhance wound healing. All this work was collected in his thesis titled "Platelet derivatives: from the Laboratory bench to the bedside".

Dr. Spanò achieved his MSc Degree in Applied Science, Medical and Pharmaceutical Biotechnology in November 2011 at the Università Degli Studi di Genova, discussing the thesis “Alteration of bone turnover and growth plate in transgenic mice overexpressing Lipocalin-2 in bone”.


Education

Title: Ph.D. in Tissue Engineering and Regenerative Medicine
Institute: Università degli Studi di Genova
Location: Genova
Country: Italy
From: 2013 To: 2016

Title: Master Degree in Applied Science, Medical and Pharmaceutical Biotechnology
Institute: Università degli Studi di Genova
Location: Genova
Country: Italy
From: 2006 To: 2011

All Publications
2022
Moore T.L., Cook A.B., Belotti E., Palomba R., Manghnani P., Spano R., Brahmachari S., Di Francesco M., Palange A.L., Di Mascolo D., Decuzzi P.
Shape-specific microfabricated particles for biomedical applications: a review
Drug Delivery and Translational Research
Article Journal
2022
Romaldini A., Spanò R., Catalano F., Villa F., Poggi A., Sabella S.
Sub-lethal concentrations of graphene oxide trigger acute-phase response and impairment of phase-I xenobiotic metabolism in Upcyte® Hepatocytes
Frontiers in Bioengineering and Biotechnology
Article Journal
2021
Di Mascolo D., Palange A.L., Primavera R., Macchi F., Catelani T., Piccardi F., Spano R., Ferreira M., Marotta R., Armirotti A., Gallotti A.L., Galli R., Wilson C., Grant G.A., Decuzzi P.
Conformable hierarchically engineered polymeric micromeshes enabling combinatorial therapies in brain tumours
Nature Nanotechnology, vol. 16, (no. 7), pp. 820-829
Article Journal
2019
Soldani G., Murzi M.b., Faita F.C., Di Lascio N.C.D., Al Kayal T.A., Spanò R., Canciani B., Losi P.
In vivo evaluation of an elastomeric small-diameter vascular graft reinforced with a highly flexible Nitinol mesh
Journal of Biomedical Materials Research - Part B Applied Biomaterials
Article Journal
2019
Contardi M., Russo D., Suarato G., Heredia-Guerrero J.A., Ceseracciu L., Penna I., Margaroli N., Summa M., Spano R., Tassistro G., Vezzulli L., Bandiera T., Bertorelli R., Athanassiou A., Bayer I.S.
Polyvinylpyrrolidone/hyaluronic acid-based bilayer constructs for sequential delivery of cutaneous antiseptic and antibiotic
Chemical Engineering Journal, vol. 358, pp. 912-923
Article Journal