Publications and Awards
Rehab Technologies Lab is an award-winning research line of IIT and our teams actively support the scientific community with many publications, dissemination talks and other accomplishments.
Publications
2025
Rinaldi F., Balboni B., Girotto S., Cavalli A.
An integrative structural study of RAD52, an emerging target in anticancer drug discovery
XXIX National Meeting on Medicinal Chemistry of the Italian Chemistry Society
Poster
Conference
2025
Milordini G., Zacco E., Armaos A., Di Palma F., Masi M., Gilodi M., Rupert J., Broglia L., Varignani G., Oneto M., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment
bioRxiv
2025
Rinaldi F., Balboni B., Marotta R., Girotto S., Cavalli A.
Elucidating RAD52 architecture through an integrated structural biology approach
51st Meeting of the Italian Crystallographic Association
Poster
Conference
2025
Bresciani V., Rinaldi F., Franco P., Girotto S., Cavalli A., Langer J. D., Masetti M., Bernetti M.
Integrating computational and experimental biophysics reveals novel insights into the RAD51-BRC4 interaction
BiorXiv
2025
Masi M., Poppi L., Previtali V., Nelson S.R., Wynne K., Varignani G., Falchi F., Veronesi M., Albanesi E., Tedesco D., De Franco F., Ciamarone A., Myers S.H., Ortega J.A., Bagnolini G., Ferrandi G., Farabegoli F., Tirelli N., Di Stefano G., Oliviero G., Walsh N., Roberti M., Girotto S., Cavalli A.
Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity
Cell Death Discovery, vol. 11, (no. 1)
2025
Codino A., Spagnoletti L., Olobardi C., Cuomo A., Santos-Rosa H., Palomba M., Margaroli N., Girotto S., Scarpelli R., Luan S.-L., Crocco E., Bianchini P., Bannister A.J., Gustincich S., Kouzarides T., Rizzo R., Barbieri I., Cremisi F., Vignali R., Pandolfini L.
METTL9 sustains vertebrate neural development primarily via non-catalytic functions
Nature Communications, vol. 16, (no. 1)
2025
Rinaldi F., Bresciani V., Franco P., Veronesi M., Bernetti M., Masetti M., Langer J., Cavalli A., Girotto S.
Probing the BRC repeats RAD51 interaction by integrating computational and experimental biophysics
The 49th FEBS Congress
Poster
Conference
2025
Di Martino R.M.C., Russo D., Penna I., Demuro S., Dalle Vedove A., Spagnuolo R., Ottonello G., Bertozzi S.M., Summa M., Desantis J., Valeri A., Pruccoli L., Tripathi S.K., Tarozzi A., Storici P., Girotto S., Bertorelli R., Armirotti A., Cruciani G., Bandiera T., Cavalli A., Bottegoni G.
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies
European Journal of Medicinal Chemistry, vol. 297
2025
Romeo E., Saccoliti F., Andonaia A., Allegretta C., Occello R., Pastorino C., Pedemonte N., Girotto S., Falchi F., Laselva O., Bandiera T., Bertozzi F.
Target identification with live-cell photo-affinity labelling and elucidation of the mechanism of action of the CFTR corrector ARN23765
EFMC-ISCB
Poster
Conference
2025
Rinaldi F., Bernetti M., Bresciani V., Veronesi M., Masetti M., Girotto S., Cavalli A.
The mechanistic understanding of the BRCA2-RAD51 interaction: an integrated structural biophysics study
Mammalian DNA Repair Gordon Research Conference: DNA Repair: Fundamental Mechanisms and Human Biology
Poster
Conference
2024
Bagnolini G., Poppi L., Previtali V., Ferrandi G., Rinaldi F., Girotto S., Hirsch A.K.H., Roberti M., Cavalli A.
A journey through targeting BRCA2-RAD51 protein-protein interaction to establish synthetic lethality as paradigm for anticancer drug discovery
National Congress of the Italian Chemistry Society 2024
Poster
Conference
2024
Rinaldi F., Bernetti M., Bresciani V., Girotto S., Cavalli A.
An integrated structural approach reveals novel insights on the BRCA2 - RAD51 interaction
EMBO Practical Course on Small Angle Neutron and X-ray Scattering from biomacromolecules in solution
Poster
Conference
2024
Balboni B., Marotta R., Rinaldi F., Milordini G., Varignani G., Girotto S., Cavalli A.
An integrative structural study of the human full-length RAD52 at 2.2 Å resolution
Communications Biology, vol. 7, (no. 1)
2024
Quaia R., Veronesi M., Anselmi M., Russo D., Penna I., Scarpelli R., Girotto S., Duca M., Bertozzi F., Bandiera T.
Developmental of fluorinated fragments into novel modulators of micro-RNA-21 levels
RNA Technologies Flagship, 2nd Annual Retreat, Genova
Poster
Conference
2024
Brindani N., Vuong L.M., La Serra M.A., Salvador N., Menichetti A., Acquistapace I.M., Ortega J.A., Veronesi M., Bertozzi S.M., Summa M., Girotto S., Bertorelli R., Armirotti A., Ganesan A.K., De Vivo M.
Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy
Journal of Medicinal Chemistry, vol. 67, (no. 12), pp. 10401-10424
Awards
2024
Macaluso A., Bottino A., Pratticò F.G., Lamberti F., Galletti C., Storchi C., Podda J., Tacchino A., Brichetto G., Boccardo N., et al.
Best Session Presentation - Executive Control in a Mixed Reality Exergame for Motor-Cognitive Rehabilitation in Multiple Sclerosis
2022
Maludrottu S., Laffranchi M., Vassallo C., Vaccaro R., De Michieli L.
iF DESIGN AWARD 2022 - Twin Exoskeleton
2021
Laffranchi M., Traverso S., Vaccaro R., Maludrottu S., Poli F., De Bartolomeis L., Diamanti G., Gruppioni E., De Michieli L.
Good Design
2020
Laffranchi M.
Robotics 2020 Young Investigator Award
2020
Laffranchi M., Boccardo N., Traverso S., Lombardi L., Canepa M., Lince A., Semprini M., Saglia J.A., Naceri A., Sacchetti R., et al.
XXVI Compasso d'oro
2019
Colombi I.
PhD thesis award in Neuroengineering "MASSIMO GRATTAROLA" (17^ Ed.)
2018
Laffranchi M., Boccardo N., Traverso S., Lince A., Canepa M., Saglia J., Gruppioni E., Sacchetti R., Diamanti G., Poli F., et al.
ADI Design Index
2018
Laffranchi M., Boccardo N., Traverso S., Lombardi L., Canepa M., Lince A., Semprini M., Saglia J.A., Naceri A., Sacchetti R., et al.
ADI Design Index
2018
Laffranchi M., Boccardo N., Traverso S., Lombardi L., Canepa M., Lince A., Semprini M., Saglia J.A., Naceri A., Sacchetti R., et al.
Good Design
2018
Semprini M.
selected as "reviewer of the year" for Journal of Neural Engineering