Publications and Awards
Rehab Technologies Lab is an award-winning research line of IIT and our teams actively support the scientific community with many publications, dissemination talks and other accomplishments.
Publications
2026
Milordini G., Zacco E., Masi M., Armaos A., Di Palma F., Oneto M., Gilodi M., Rupert J., Broglia L., Varignani G., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction impair homologous recombination and induce synthetic lethality
Nature Communications, vol. 17, (no. 1)
2025
Rinaldi F., Balboni B., Varignani G., Milordini G., Marotta R., Girotto S., Cavalli A.
An integrative structural study of RAD52, an emerging target in anticancer drug discovery
XXIX National Meeting on Medicinal Chemistry of the Italian Chemistry Society
Poster
Conference
2025
Rinaldi F., Balboni B., Girotto S., Cavalli A.
An integrative structural study of RAD52, an emerging target in anticancer drug discovery
XXIX National Meeting on Medicinal Chemistry of the Italian Chemistry Society
Poster
Conference
2025
Rinaldi F., Franco P., Veronesi M., Romeo E., Bresciani V., Varignani G., Catalano F., Bernetti M., Masetti M., Langer J. D., Girotto S., Cavalli A.
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination
Research Square
Article
E-print Archive
2025
Cianci F., Verduci I., Cazzoli R., Cannavale G., Rey G., Veronesi M., Balboni B., Ranucci M., Palloni L.M.G., Ballabio F., Barsotti N., Ailuno G., Balboni A., Baldassari S., Caviglioli G., Tacconi C., Camilloni C., Girotto S., Barbieri F., Fantin A., Cavalli A., Pasqualetti M., Florio T., Minucci S., Mazzanti M.
Chronic administration of metformin exerts cytostatic and cytotoxic effects via the PP2A-GSK3β-MCL-1 pathway by inhibiting the tmCLIC1 membrane protein in glioblastoma-initiating cells
Journal of Experimental and Clinical Cancer Research, vol. 44, (no. 1)
2025
Milordini G., Zacco E., Armaos A., Di Palma F., Masi M., Gilodi M., Rupert J., Broglia L., Varignani G., Oneto M., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment
bioRxiv
2025
Torielli L., Castelli M., Milani F., Heritz J.A., Cayaban S.J., Hernandez J., Serapian S.A., Magni A., Frasnetti E., Doria F., Pirota V., Wengert L.A., Woodford M.R., Lodigiani G., Bergamaschi G., Veronesi M., Bandiera T., Girotto S., Paladino A., Prodromou C., Backe S.J., Bourboulia D., Canciani A., Arrigoni C., Lolicato M., Gestwicki J.E., Mollapour M., Colombo G.
Design of multi-target peptide modulators for protein chaperone networks
Structure
2025
Quaia R., Veronesi M., Anselmi M., Russo D., Penna I., Scarpelli R., Girotto S., Bertozzi F., Duca M., Bandiera T.
Development of fluorinated fragments into novel modulators of micro-RNA-21 levels
European School of Medicinal Chemistry – 44th Edition
Poster
Conference
2025
Anselmi M., Russo D., Penna I., Quaia R., Panosetti M., Scarpelli R., Girotto S., Veronesi M., Bertozzi F., Duca M., Bandiera T.
DISCOVERY OF NOVEL SMALL-MOLECULE MODULATORS OF microRNA-21 IN PANCREATIC CANCER CELLS
59th International Conference on Medicinal Chemistry
Poster
Conference
2025
Bresciani V., Rinaldi F., Franco P., Girotto S., Cavalli A., Langer J. D., Masetti M., Bernetti M.
Dissecting the RAD51-BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics
Journal of Chemical Information and Modeling
Article
Journal
2025
Bresciani V., Rinaldi F., Franco P., Girotto S., Cavalli A., Langer J.D., Masetti M., Bernetti M.
Dissecting the RAD51–BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics
Journal of Chemical Information and Modeling, vol. 65, (no. 21), pp. 11965-11978
2025
Rinaldi F., Balboni B., Marotta R., Girotto S., Cavalli A.
Elucidating RAD52 architecture through an integrated structural biology approach
51st Meeting of the Italian Crystallographic Association
Poster
Conference
2025
Quatraccioni M., Ocello R., Falchi F., Previtali V., Veronesi M., Varignani G., Margaroli N., Masi M., Scarpelli R., Girotto S., Cavalli A.
In search of small molecules targeting RAD52 for synthetic lethality (P120)- September 14-17, 2025, Parma (Italy)
XXIX National Meeting on Medicinal Chemistry
Poster
Conference
2025
Bresciani V., Rinaldi F., Franco P., Girotto S., Cavalli A., Langer J. D., Masetti M., Bernetti M.
Integrating computational and experimental biophysics reveals novel insights into the RAD51-BRC4 interaction
BiorXiv
2025
Masi M., Poppi L., Previtali V., Nelson S.R., Wynne K., Varignani G., Falchi F., Veronesi M., Albanesi E., Tedesco D., De Franco F., Ciamarone A., Myers S.H., Ortega J.A., Bagnolini G., Ferrandi G., Farabegoli F., Tirelli N., Di Stefano G., Oliviero G., Walsh N., Roberti M., Girotto S., Cavalli A.
Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity
Cell Death Discovery, vol. 11, (no. 1)
2025
Codino A., Spagnoletti L., Olobardi C., Cuomo A., Santos-Rosa H., Palomba M., Margaroli N., Girotto S., Scarpelli R., Luan S.-L., Crocco E., Bianchini P., Bannister A.J., Gustincich S., Kouzarides T., Rizzo R., Barbieri I., Cremisi F., Vignali R., Pandolfini L.
METTL9 sustains vertebrate neural development primarily via non-catalytic functions
Nature Communications, vol. 16, (no. 1)
2025
Rinaldi F., Bresciani V., Franco P., Veronesi M., Bernetti M., Masetti M., Langer J., Cavalli A., Girotto S.
Probing the BRC repeats RAD51 interaction by integrating computational and experimental biophysics
The 49th FEBS Congress
Poster
Conference
2025
Di Martino R.M.C., Russo D., Penna I., Demuro S., Dalle Vedove A., Spagnuolo R., Ottonello G., Bertozzi S.M., Summa M., Desantis J., Valeri A., Pruccoli L., Tripathi S.K., Tarozzi A., Storici P., Girotto S., Bertorelli R., Armirotti A., Cruciani G., Bandiera T., Cavalli A., Bottegoni G.
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies
European Journal of Medicinal Chemistry, vol. 297
Awards
2025
Rehab Technologies.
ADI Index award - Hannes arm
2025
Laffranchi M., Traverso S., Vaccaro R., Cavallaro L., Canepa M., Boccardo N., Vassallo C., Maludrottu S., De Michieli L., Gruppioni E.
Compasso d'oro international award - Twin exoskeleton
2025
Semprini M.
EMBC Distinguished Lecturer
2025
Laffranchi M.
Premio ANGI 2025 - Menzione speciale innovazione "Innovation leader award"
2024
Macaluso A., Bottino A., Pratticò F.G., Lamberti F., Galletti C., Storchi C., Podda J., Tacchino A., Brichetto G., Boccardo N., et al.
Best Session Presentation - Executive Control in a Mixed Reality Exergame for Motor-Cognitive Rehabilitation in Multiple Sclerosis
2024
Vassallo C.
Tornare a camminare grazie a un esoscheletro
2024
Vassallo C.
User-Centered Design and Development of Medical Robots: Rehabilitative Exoskeletons and Prostheses
2024
Franconi B., Cherubini A., Sacchini A., De Giuseppe S., Bunt A., Berettoni A., Modica A., Boccardo N., Gruppioni E., Traverso S., et al.
Winner of the 2024 Cybathlon Leg Prosthesis Race
2022
Maludrottu S., Laffranchi M., Vassallo C., Vaccaro R., De Michieli L.
iF DESIGN AWARD 2022 - Twin Exoskeleton
2021
Laffranchi M., Traverso S., Vaccaro R., Maludrottu S., Poli F., De Bartolomeis L., Diamanti G., Gruppioni E., De Michieli L.
Good Design